Labdane Diterpenes from the Fruits of Sinopodophyllum emodi.

نویسندگان

  • Yan-Jun Sun
  • Mei-Ling Gao
  • Yan-Li Zhang
  • Jun-Min Wang
  • Ya Wu
  • Yu Wang
  • Tao Liu
چکیده

Two new labdane diterpenes, sinoditerpene A (1) and B (2), were isolated from the fruits of Sinopodophyllum emodi, along with two known analogues 3 and 4. Their structures were established on the basis of extensive spectroscopic analysis. The isolation of compounds 1-4 represents the first report of diterpenes from the genus Sinopodophyllum. The cytotoxic activities of all isolated compounds were evaluated in comparison with 5-fluorouracil against the MCF-7 and HepG2 cell lines, towards which 3 showed more potent cytotoxicity.

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عنوان ژورنال:
  • Molecules

دوره 21 4  شماره 

صفحات  -

تاریخ انتشار 2016